The principle of X-ray free electron lasers and their applications in biological molecular structure determination

SHI Ying-Chen; LIU Hai-Guang

doi:10.7693/wl20180703

PHYSICS > 2018 > 47(7): 426-436. > DOI: 10.7693/wl20180703

SHI Ying-Chen, LIU Hai-Guang. The principle of X-ray free electron lasers and their applications in biological molecular structure determination[J]. PHYSICS, 2018, 47(7): 426-436. DOI: 10.7693/wl20180703

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The principle of X-ray free electron lasers and their applications in biological molecular structure determination

SHI Ying-Chen,
LIU Hai-Guang^†

Beijing Computational Science Research Center,Division of Complex Systems,Beijing 100193,China

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Received Date: October 31, 2017
Published Date: July 11, 2018

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Abstract

As an electromagnetic wave of short wavelength and high energy, X-rays have been used to probe the fine structure of materials and biological macromolecules for over a century. The first hard X-ray free electron laser (XFEL) facility in the Stanford Linear Accelerator Center national laboratory was commissioned in 2009, and since then its cutting-edge technology has provided highly brilliant, ultrashort pulsed, and fully coherent X-rays, transforming many research fields by expanding the capability of studying fine structures at high temporal and spatial resolutions. The number of XFEL facilities constructed or planned is growing rapidly around the world. In this article, we will explain the principle of an XFEL and summarize the major characteristics of X-rays generated by XFELs. With their unique properties, several milestones have been achieved in the application of XFELs in visualizing the structure and dynamics of molecules in biological sciences.
- X-ray free electron laser,
- single particle imaging,
- serial femtosecond crystallography,
- time-resolved crystallography

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References

[1]	Winick H，Brown G，Halbach K et al. Physics Today，1981，34(5)：50
[2]	Milton S V，Yang B X. Science，2001，292(5524)：2037
[3]	Pellegrini C. Physica Scripta，2017，169：014004
[4]	Ball P. Nature，2017，548(7669)：507
[5]	https：//portal.slac.stanford.edu/sites/lclscore_public/Accelerator_Physics_Published_Documents/Forms/AllItems.aspx
[6]	Howells M R，Beetz T，Chapman H N et al. Journal of Electron Spectroscopy & Related Phenomena，2009，170(1-3)：4
[7]	Neutze R，Wouts R，Spoel D V D et al. Nature，2000，406(6797)：752
[8]	Chapman H N，Barty A，Bogan M J et al. Nature Physics，2006，2(12)：839
[9]	Seibert M M，Ekeberg T，Maia F R et al. Nature，2011，470(7332)：78
[10]	Liu H G，Spence J C H. Quantitative Biology，2016，4(3)：1
[11]	Deponte D P，Mckeown J T，Weierstall U et al. Ultramicroscopy，2011，111(7)：824
[12]	Spence J C，Weierstall U，Chapman H N. Reports on Progress in Physics Physical Society，2012，75(10)：102601
[13]	Ekeberg T，Svenda M，Abergel C et al. Physical Review Letters，2015，114(9)：098102
[14]	Bohren C F，Huffman D R. Journal of Colloid & Interface Science，1984，98(1)：290
[15]	Huldt G，Szoke A，Hajdu J. Journal of Structural Biology，2003，144(1-2)：219
[16]	Reddy H K N，Yoon C H，Aquila A et al. Scientific Data，2017，4：170079
[17]	Bortel G，Tegze M. Acta Crystallographica，2011，67(Pt 6)：533
[18]	Loh N T，Elser V. Physical Review E Statistical Nonlinear & Soft Matter Physics，2009，80(2 Pt 2)：026705
[19]	Ayyer K，Lan T Y，Elser V et al. Journal of Applied Crystallography，2016，49(4)：1320
[20]	Giannakis D，Schwander P，Ourmazd A. Optics Express，2012，20(12)：12827
[21]	Hosseinizadeh A，Mashayekhi G，Copperman J et al. Nature Methods，2017，14(9)：877
[22]	Maia F R N C，Ekeberg T，Spoel D V D et al. Journal of Applied Crystallography，2010，43(6)：1535
[23]	Fienup J R. Applied Optics，1982，21(15)：2758
[24]	Marchesini S，He H，Chapman H N et al. Physical Review B，2003，68(14)：399
[25]	Kassemeyer S，Jafarpour A，Lomb L et al. Physical Review E Statistical Nonlinear & Soft Matter Physics，2013，88(1)：042710
[26]	Li X X，Chiu C Y，Wang H J et al. Scientific Data，2017，4：170048
[27]	Daurer B J，Okamoto K，Bielecki J et al. Iucrj，2017，4(Pt 3)：251
[28]	Kam Z. Macromolecules，1977，10(5)：927
[29]	Liu H G，Poon B K，Saldin D K et al. Acta Crystallographica Section A，2013，69(4)：365
[30]	Kurta R P，Donatelli J J，Yoon C H et al. Physical Review Letters，2017，119(15)：158102
[31]	Rose P W，Prlić A，Altunkaya A et al. Nucleic Acids Research，2017，45(D1)：D271
[32]	Chapman H N，Fromme P，Barty A et al. Nature，2011，470(7332)：73
[33]	Boutet S，Lomb L，Williams G J et al. Science，2012，337(6092)：362
[34]	Suga M，Akita F，Hirata K et al. Nature，2015，517(7532)：99
[35]	Barty A，Kirian R A，Maia F R N C et al. Journal of Applied Crystallography，2014，47(3)：1118
[36]	Foucar L，Barty A，Coppola N et al. Computer Physics Communications，2012，183(10)：2207
[37]	Sauter N K，Hattne J，Grossekunstleve R W et al. Acta Crystallographica，2013，69(7)：1274
[38]	Steller I，Bolotovsky R，Rossmann M G. Journal of Applied Crystallography，1997，30(6)：1036
[39]	KabschW. Journal of Applied Crystallography，1993，26(6)：795
[40]	Brehm W，Diederichs K. Acta Crystallographica，2014，70(1)：101
[41]	Liu H，Spence J C. Iucrj，2014，1(Pt 6)：393
[42]	White T A. Philos. Trans. R. Soc. Lond. B. Biol. Sci.，2014，369(1647)：20130330
[43]	Sauter N K，Hattne J，Grossekunstleve R W et al. Acta Crystallographica，2013，69(7)：1274
[44]	Helen Mary G，Brewster A S，Johan H et al. Acta Crystallogr. D Biol. Crystallogr.，2015，71(Pt 6)：1400
[45]	Rossmann M G. Acta Crystallographica，1990，46(2)：73
[46]	Hendrickson W A，Ogata C M. Methods Enzymol.，1997，276：494
[47]	Spence J C，Kirian R A，Wang X et al. Optics Express，2011，19(4)：2866
[48]	White T A，Kirian R A，Martin A V et al. Journal of Applied Crystallography，2012，45(2)：335
[49]	Sauter N K. Journal of Synchrotron Radiation，2015，22(2)：239
[50]	Adams P D，Afonine P V，Bunkóczi G et al. Acta Crystallographica，2010，66(Pt 2)：213
[51]	Aquila A，Hunter M S，Doak R B et al. Optics Express，2012，20(3)：2706
[52]	Tenboer J，Basu S，Zatsepin N et al. Science，2014，346(6214)：1242
[53]	Pande K，Hutchison C D M，Groenhof G et al. Science，2016，352(6286)：725
[54]	Stagno J R，Liu Y，Bhandari Y R et al. Nature，2017，541(7636)：242

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